Grape-Derived Compounds to Help Beat Depression

By Dr. Mercola

A polyphenol preparation made from Concord grape juice, grape seed extract and trans-resveratrol has shown promise for treating depression, according to an animal study from the Icahn School of Medicine at Mount Sinai.1 Two phytochemicals in particular — dihydrocaffeic acid (DHCA) and malvidin-3′-O-glucoside (Mal-gluc) — appeared to be responsible for the beneficial effects, which included modulating inflammation and synaptic plasticity, essentially increasing resilience against stress-induced depression in mice.2

Previous research has found that a single dose of resveratrol can improve blood flow to your brain and may enhance several aspects of brain function, including lowered inflammation that may extend to protection again depression.3 The featured study revealed that the grape-derived compounds target cellular and molecular pathways associated with inflammation while modulating synaptic plasticity, disruptions of which have been linked to depression.

DHCA was found to reduce a pro-inflammatory compound called interleukin 6 (IL-6) while Mal-gluc modulates synaptic

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